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Nasal gel formulation pdf writer
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The formulation with P407 (16.0-24.0%) and P188 (1.0-8.0%) formed a semisolid transparent gel at a certain temperature. The gelation temperature decreased gradually as the P407 concentration increased. However, the temperature increased as the P188 concentration increased.
filexlib. Formulation and Evaluation of Nasal in Situ Gel of Phenylephrine
Formulation was developed to reduce the mucociliary clearance by using mucoadhesive polymer in gel, thereby increasing the contact time with nasal mucosa and hence improving the absorption of drug. 16 Development and evaluation of mucoadhesive nasal gel of felodipine prepared with the mucoadhesive substance of dillleniaindica L
IN SITU GEL -SUSTAINED NASAL DRUG DELIVERY Abstract. In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the nasal cavity, but once administered, undergo gelation in situ, to form a gel.The formation of gel depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets
The nasal route is an important mode of drug delivery, with a growing number of products available for administration through the route for systemic and local administration. In-situ gel is a new dosage form which has been applied in nasal drug delivery recently. Compared with liquid nasal formulation nasal in-situ gels
View PDF PDF; Abstract. This study revealed that the gel strength of nasal gel formulation is at 33-34 °C, increased as the concentration of gellan gum increased. In vitro drug release study. The in vitro release was carried out for all formulation using phosphate buffer pH 6.4 as medium.
the pH of the formulations was adjusted between 4.5 and 5.5 using 0.1N HCl. The developed formulations were stored in refrigerator for further studies. Characterization of in situ gel: Gelation studies by visual inspection: Briefly, a 10 ml transparent vial with a magnetic bar was taken and the formulations were placed in it. to prepare nasal in situgel of Phenylephrine hydrochloride for the treatment of respiratory tract infections especially for sinusitis and bronchitis to attain site specific action and to sustain the drug release for a prolong period which decreases the frequency of dosage
Formulation and Characterization of Nasal Sprays
The aim of this study was to develop an intranasal in situ thermo-gelling meloxicam-human serum albumin (MEL-HSA) nanoparticulate formulation applying poloxamer 407 (P407), which can be administered in liquid state into the nostril, and to increase the resistance of the formulation against mucociliary clearance by sol-gel transition on the nasal mucosa, as well as to improve drug absorption.
inflammatory activity. However, the Xanthan gum based gel proved to the formula of choice, since it showed the highest percentage of extrudability, good spreadability and rheological properties. Formulation F5 with 1 % leaves extract and F11 with 1% root extract of Clerodendrum serratum showed the best formulation with significant anti-inflammatory
The pH of various gel formulations was determined by using digital pH meter. One gram of gel was dissolved in 100 ml distilled water and stored for two hours. The measurement of pH of each formulation was done in triplicate and average values are calculated. B. Drug Content : 1 g of the prepared gel was mixed with 100ml of suitable solvent.
The pH of various gel formulations was determined by using digital pH meter. One gram of gel was dissolved in 100 ml distilled water and stored for two hours. The measurement of pH of each formulation was done in triplicate and average values are calculated. B. Drug Content : 1 g of the prepared gel was mixed with 100ml of suitable solvent.
the gel across the goat’s nasal mucosa. In histopathological study no effect of surfactant was seen; neither had the formulations caused any damage to the nasal tissue. Hence we can conclude that the niosomal in-situ nasal gel system can be considered as a promising approach for the anti-epileptic drug Valproic Acid.

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